Hypothalamic histamine modulates delayed suppression of feeding following administration of 2-deoxy-D-glucose
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Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration.
Ghrelin, an endogenous ligand for the GH secretagogue receptor, is a hormone expressed in stomach and other tissues, such as hypothalamus, testis, and placenta. This hormone acts at a central level to stimulate GH secretion and food intake. Little is known, however, about the molecular forms and physiological roles of ghrelin within the hypothalamus. In this report, we detail the molecular form...
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BACKGROUND During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need, the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) on in vitro and in vivo angiogenesis were investigated. METHODOLOGY...
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SMITH, GERARD P., JAMES GIBBS, ALAN J. STROHMAYER, AND PETER E. STOKES. Threshold doses of 2-deoxy-D-glucose for hyper$ycemia and feeding in rats and monkeys. Am. J. Physiol. 222(l): 77-81. 1972.~Injection of the glucose analogue, 2-deoxy-nglucose (2-DG) , into intact mammals produces a metabolic \tate of glucoprivation characterized by extracellular hyperrlycemia and decreased intracellular gl...
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Feeding was induced with lateral intracerebroventricular (ICV) injections of 2-deoxy-D-glucose (2-dg), a glucose analogue causing glucoprivation. Feeding increased rapidly by an average of 2.6 g following ICV 2-DG (2.9 or 5.8 mg per rat), but did not increase after ICV D-glucose or sucrose. At the same doses, 2-DG did not increase feeding when given peripherally. Core temperature dropped in a d...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1992
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)49135-x